Vaccine & Gene Therapy InstituteOregon Health & Science University United States of Americapickerl@ohsu.edu
Dr. Louis J. Picker is currently the Associate Director of the Vaccine and Gene Therapy Institute, a Senior Scientist in the Pathobiology and Immunology Division of the Oregon National Primate Research Center, and a Professor in the Oregon Health & Science University’s Departments of Pathology and Molecular Microbiology and Immunology. Dr. Picker was recruited to OHSU in 2000 from the Department of Pathology at the University of Texas Southwestern Medical Center at Dallas where he served as a Principal Investigator, Medical Director of the Flow Cytometry and Clinical Immunology Laboratory, and Co-Director of the Division of Hematopathology and Immunology. He received his medical degree at the University of California, San Francisco in 1982, did an internship, residency, and chief residency in Anatomic and Clinical Pathology at the Beth Israel Hospital and Harvard Medical School in Boston, Massachusetts from 1982-86, and received advanced training in Immunopathology and Experimental Pathology at Stanford University Medical Center in Palo Alto, California from 1986-89. Dr. Picker is well known for his work elucidating human/nonhuman primate (NHP) memory T cell biology (including mechanisms of memory T cell homing, functional differentiation and homeostasis, mechanisms of protection against persistent pathogens, and the immuno-pathogenesis of AIDS), and developing HIV/AIDS vaccine concepts. He has authored over 180 journal articles in these areas. Of note, Dr. Picker was the discoverer of the skin-selective homing receptor CLA, the developer of the cytokine flow cytometry assay for quantification of Ag-specific T cells in humans and NHP, and has pioneered “effector memory”-biased T cell (TEM) vaccines and the use of Cytomegalovirus vectors to generate and maintain such TEM responses, as well as to program unconventionally targeted CD8+ T cell responses.