Keynote and Invited speakers

speaker19 Dana Wolf

Head, Clinical Virology Unit
Dept. of clinical Microbiology & Infectious Diseases
Hadassah University Hospital
Jerusalem
Israel
dana.wolf@ekmd.huji.ac.il

Interaction and manipulation of the CMV with the immune system of the baby is involved in majority of the cCMV complications, there is a question how CMV influence the post-natal development of the pre-term babies. Aim of out study was to find out the frequency of CMV among the babies at Neonatal Intensive care Unit (NICU).

Between July 2016 and January 2017, we obtained 96 samples of mother’s milk (MM) from 69 mothers and 117 urine/urine containing surgical swabs after inserting into the nappy from 83 newborns (39 girls and 44 boys) shortly after the delivery with median 1 day of age in urine samples (range 0-104 days) and 5 days of age in MM (range 0-53 days). There were 14 twins in the cohort. CMV DNA detection was performed by PCR and validity of the detection was controlled by detection of the human albumine gene in the sample.

Validity of the testing failed in 9 urine samples. CMV was detected in 4 urine samples from 3 infants (at the age of 38, 48 and 59 days) and 30 MM samples from 20 babies (16 mothers – 23.2%; median at the first positive sample was 10 days; range 1-35). In 7 mothers, CMV was detected in MM repeatedly (longest detected period 62 days). In two infants CMV detection preceded CMV in MM in detection urine for 35 and 53 days.

Despite the freezing of the MM before feeding the babies at NICU, we detected CMV in approx. 4% of the tested neonates. Recently, we are working on the genotyping of CMV both from MM and urine samples to prove the infection from MM or infection from another source and analysing the clinical features and complications observed in the infants.

Supported by the project for conceptual development of research organization 00064203.


Sessions

Volledige programa

CMV 2017: the 6th International congenital CMV conference/16th International CMV/betaherpesvirus workshop in 2017<